PXD046778-2

PXD046778 is an original dataset announced via ProteomeXchange.

Title	Ablation of integrin-mediated cell–collagen communication alleviates fibrosis
Description	Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce biochemical and mechanical signals enabling cells to mount appropriate responses according to biological demands. The aim of this work was to investigate the in vivo role of collagen–fibroblast interactions for regulating fibroblast functions and fibrosis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:13:42.376.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilian Atanassov
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-08 03:34:00	ID requested
1	2023-11-08 04:02:37	announced
⏵ 2	2023-11-14 09:13:45	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:13:50	announced	2024-10-22: Updated project metadata.

Sawant M, Wang F, Koester J, Niehoff A, Nava MM, Lundgren-Akerlund E, Gullberg D, Leitinger B, Wickstr, ö, m S, Eckes B, Krieg T, Ablation of integrin-mediated cell-collagen communication alleviates fibrosis. Ann Rheum Dis, 82(11):1474-1486(2023) [pubmed]

submitter keyword: fibrisis, TMT,integrin

Prof. Dr. Thomas Krieg
contact affiliation	Translational Matrix Biology, University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany
contact email	thomas.krieg@uni-koeln.de
lab head
Ilian Atanassov
contact affiliation	Max Planck Institute for Biology of Aging
contact email	Ilian.Atanassov@age.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD046778

PRIDE project URI

• PRIDE
  1. PXD046778
     1. Label: PRIDE project
     2. Name: Ablation of integrin-mediated cell–collagen communication alleviates fibrosis