PXD046746-1

PXD046746 is an original dataset announced via ProteomeXchange.

Title	Circulating levels of the proinflammatory monomeric isoform of C-reactive protein (mCRP) correlate with intra-tumoral mCRP abundance in stage II-III colon cancer patients
Description	Elevated levels of circulating C-reactive protein (CRP) are associated with worse outcome for patients with colorectal cancer (CRC). Monomeric CRP (mCRP) has been demonstrated in tissues of various diseases, including colon cancer (CC). mCRP possesses proinflammatory properties and potentially contributes to tumour-promoting inflammation. Although considered tissue-based, mCRP can exist in the circulation bound to membranes or as aggregates. This project aimed to detect and quantify circulating mCRP in CC patients by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2025-06-16
AnnouncementXML	Submission_2025-06-15_16:26:49.703.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manuel Ramirez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker software

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-07 07:21:50	ID requested
⏵ 1	2025-06-15 16:26:50	announced

10.2147/jir.s485050;

Fuglestad AJ, Bousquet PA, K, ø, stner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C, Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients. J Inflamm Res, 18():7115-7125(2025) [pubmed]

submitter keyword: Colon cancer, inflammation, monomeric C-reactive protein, C-reative protein, biomarker

Anniken Jørlo Fuglestad
contact affiliation	Institute of Clinical Medicine, University of Oslo, Oslo, Norway
contact email	a.j.fuglestad@studmed.uio.no
lab head
Manuel Ramirez
contact affiliation	University of Oslo
contact email	manuelra@uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD046746

PRIDE project URI

• PRIDE
  1. PXD046746
     1. Label: PRIDE project
     2. Name: Circulating levels of the proinflammatory monomeric isoform of C-reactive protein (mCRP) correlate with intra-tumoral mCRP abundance in stage II-III colon cancer patients