PXD046558-1

PXD046558 is an original dataset announced via ProteomeXchange.

Title	Effect of soluble egg antigen (SEA) from S. japonicum on gene expression in hepatic progenitor cells (HPC) cell line LE/6 and WB-F344
Description	Schistosomiasis is a serious but neglected tropical disease, which can cause granulomatous lesions and hepatic fibrosis. The egg-induced liver fibrosis is the primary cause of mortality and morbidity associated with this chronic disease. HPCs are a kind of stem cells with potentially bidirectional differentiation ability and interact with hepatic stellate cells during liver injury. We here reported the activation of HPCs during S. japonicum-induced liver fibrosis. SEA was used to stimulate HPC cell line LE/6 and WB-F344, and the differentiated gene expressions were shown to display the effect. Taken together, our data provides a moelcular framwork for SEA stimulation on HPCs during S. japonicum infection.
HostingRepository	iProX
AnnounceDate	2023-11-01
AnnouncementXML	Submission_2024-04-07_20:59:21.978.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yua Yuan
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-31 19:52:39	ID requested
⏵ 1	2024-04-07 20:59:22	announced

Dataset with its publication pending

submitter keyword: schistosoma, liver fibrosis, hepatic progenitor cell

Qian Chen
contact affiliation	Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST)
contact email	601428533@qq.com
lab head
Yua Yuan
contact affiliation	Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST)
contact email	m15521257192@163.com
dataset submitter

iProX dataset URI