PXD046539-1

PXD046539 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Whole proteome of MDK model mice
Description	MDK is a heparin-binding growth factor and found to be the Aβ associated protein. AD mouse model of MDK knockout was established to provide the animal tool to investigate the effect of MDK on AD. Through proteome, we aim to study the Aβ change and identify the DE proteins by MDK knockout to know how MDK affect AD.
HostingRepository	PRIDE
AnnounceDate	2025-07-16
AnnouncementXML	Submission_2025-07-15_18:57:46.281.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shu Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-31 09:24:47	ID requested
⏵ 1	2025-07-15 18:57:47	announced

Publication List

Zaman M, Yang S, Huang Y, Yarbro JM, Hao Y, Wang Z, Liu D, Harper KE, Soliman H, Hemphill A, Harvey S, Pruett-Miller SM, Stewart V, Tanwar AS, Kalathur R, Grace CR, Turk M, Chittori S, Jiao Y, Wu Z, High AA, Wang X, Serrano GE, Beach TG, Yu G, Yang Y, Chen PC, Peng J, Fibril Assembly and Amyloid Plaque Formation. bioRxiv, ():(2025) [pubmed]
10.1101/2025.03.20.644383;

Zaman M, Yang S, Huang Y, Yarbro JM, Hao Y, Wang Z, Liu D, Harper KE, Soliman H, Hemphill A, Harvey S, Pruett-Miller SM, Stewart V, Tanwar AS, Kalathur R, Grace CR, Turk M, Chittori S, Jiao Y, Wu Z, High AA, Wang X, Serrano GE, Beach TG, Yu G, Yang Y, Chen PC, Peng J, Fibril Assembly and Amyloid Plaque Formation. bioRxiv, ():(2025) [pubmed]

10.1101/2025.03.20.644383;

Keyword List

submitter keyword: whole proteome,MDK, mice

submitter keyword: whole proteome,MDK, mice

Contact List

Junmin Peng
contact affiliation	Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA
contact email	junmin.peng@stjude.org
lab head
Shu Yang
contact affiliation	St. Jude Childern's Research Hospital
contact email	shuyang0104@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD046539
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD046539

PRIDE project URI

Repository Record List

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