PXD046529-1

PXD046529 is an original dataset announced via ProteomeXchange.

Title	The interaction between DNMT3A with H3Kc36me2 modified nucleosomes
Description	DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns, essential for the dynamic organization of vertebrate genomes. However, the mechanisms underlying DNMT3A1's recruitment and function within different chromatin environments remain unclear. We find that DNMT3A interacts with modified nucleosomes through multivalent interactions, involving both direct binding to chromatin features and site-specific post-translational histone modifications.
HostingRepository	PRIDE
AnnounceDate	2024-12-07
AnnouncementXML	Submission_2024-12-07_05:21:23.116.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Zou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-31 05:05:11	ID requested
⏵ 1	2024-12-07 05:21:23	announced

Dataset with its publication pending

submitter keyword: DNMT3A, crosslink, nucleosomes

Juri Rappsilber
contact affiliation	University of Edinburgh, Wellcome Centre for Cell Biology, Edinburgh, UK. Technische Universität Berlin, Chair of Bioanalytics, Berlin, Germany.
contact email	juri.rappsilber@ed.ac.uk
lab head
Juan Zou
contact affiliation	The University of Edinburgh
contact email	jzou@ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD046529

PRIDE project URI

• PRIDE
  1. PXD046529
     1. Label: PRIDE project
     2. Name: The interaction between DNMT3A with H3Kc36me2 modified nucleosomes