PXD046510 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection |
Description | People with HIV (PWH) experience an increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors that contribute to or are associated with this vulnerability remain uncertain. In the general population, alterations in the glycomes of circulating IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG glycomes of cross-sectional and longitudinal samples from 1,216 women and men, both living with virally suppressed HIV and those without HIV. Our glycan-based machine learning models indicate that living with chronic HIV significantly accelerates the accumulation of pro-aging associated glycomic alterations. Consistently, PWH exhibit heightened expression of senescence associated glycan-degrading enzymes compared to their controls. These glycomic alterations correlate with elevated markers of inflammatory aging and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit reduced anti-HIV IgG-mediated innate immune functions. These findings hold significant potential for the development of glycomic based biomarkers and tools to identify and prevent premature aging and comorbidities in people living with chronic viral infections. |
HostingRepository | PRIDE |
AnnounceDate | 2024-03-21 |
AnnouncementXML | Submission_2024-03-21_07:37:39.321.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD046510 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Sergei Shalygin |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | complex glycosylation |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-30 14:51:59 | ID requested | |
⏵ 1 | 2024-03-21 07:37:39 | announced | |
Publication List
Keyword List
submitter keyword: ADCP,HIV |
Glycome |
IgG |
Inflammation |
Aging |
Biological age |
Cancer |
Subclinical 51 atherosclerosis, ADCC, ADCD |
Contact List
Mohamed Abdel-Mohsen |
contact affiliation | PI The Wistar Institute, Philadelphia, PA, USA; |
contact email | mmohsen@Wistar.org |
lab head | |
Sergei Shalygin |
contact affiliation | CCRC, UGA |
contact email | ss29810@uga.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046510
- Label: PRIDE project
- Name: Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection