PXD046422 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Analysis of GITR and OX40 signaling complexes |
Description | T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory receptors. The molecular regulation of these complex signaling networks is still incompletely understood. We identified an adaptor protein, ABIN1 as a component of the signaling complexes of GITR and OX40 co-stimulation receptors. T cells lacking ABIN1 exhibit hyper-responsiveness to TCR activation ex vivo, enhanced responses to cognate infections, and superior ability to induce experimental autoimmune diabetes in mice. We observed that ABIN1 negatively regulates NFκB and p38 pathways. The latter was at least partially responsible for the upregulation of key effector proteins, IFNG and GZMB in ABIN1-deficient T cells after TCR stimulation. Our findings reveal the intricate role of ABIN1 in T-cell regulation and its potential as a target for therapeutic fine-tuning T-cell responses. |
HostingRepository | PRIDE |
AnnounceDate | 2024-04-25 |
AnnouncementXML | Submission_2024-04-25_05:14:42.920.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Peter Draber |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | methylthiolated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-26 08:09:04 | ID requested | |
⏵ 1 | 2024-04-25 05:14:43 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: T cells |
co-stimulation |
GITR |
OX40 |
Abin1 |
MS |
Contact List
Peter Draber |
contact affiliation | Laboratory of Immunity & Cell Communication, Division BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic |
contact email | peter.draber@lf1.cuni.cz |
lab head | |
Peter Draber |
contact affiliation | BIOCEV, First Faculty of Medicine, Charles University |
contact email | peter.draber@lf1.cuni.cz |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046422
- Label: PRIDE project
- Name: Analysis of GITR and OX40 signaling complexes