PXD046388 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of pleomorphic dermal sarcoma |
Description | In this study, we aimed to unravel the molecular underpinnings of pleomorphic dermal sarcomas (PDS), rare skin tumors often seen in sun-exposed regions. Using mass spectrometry, we examined proteomic profiles of 20 samples of normal healthy skin tissue (SNT), 27 malignant melanomas (MM), 20 cutaneous squamous cell carcinomas (cSCC), and 24 PDS. Our analysis aimed to: I.) Determine the potential cell of origin for PDS by correlating protein abundance to tumor purity using both RNA- and DNA-sequencing data. II.) Investigate receptor/ligand (R/L) interactions and their related pathways, highlighting distinct signaling differences between cSCC, MM, and PDS. III.) Identify differential protein markers, such as MAP1B_HUMAN, that can distinguish between cSCC, MM, and PDS. IV.) Explore proteins linked to immunosuppression in PDS, with a focus on those related to the negative regulation of interferon-gamma signaling. Together, this comprehensive proteomic exploration provides valuable insights into PDS and potential therapeutic targets. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-16 |
AnnouncementXML | Submission_2024-06-15_23:52:01.468.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Prerana Wagle |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-25 08:11:24 | ID requested | |
⏵ 1 | 2024-06-15 23:52:02 | announced | |
Publication List
Klein S, Tolkach Y, Reinhardt HC, Buettner R, Quaas A, Helbig D, Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms. Sci Rep, 14(1):12516(2024) [pubmed] |
10.1038/s41598-024-62927-x; |
Keyword List
submitter keyword: Immune Evasion, Protein Analysis, Fibroblastic lineage,Pleomorphic Dermal Sarcoma (PDS) |
Contact List
Sebastian Klein |
contact affiliation | Department of Hematology and Stem Cell Transplantation, University Duisburg-Essen, University Hospital Essen, Essen, Germany; West German Cancer Center Network, Partner Site Essen; Institute for Pathology and Neuropathology, University Hospital and Medical Faculty Cologne, Kerpenerstr 62 50937 Cologne, Germany |
contact email | Sebastian.Klein@uk-essen.de |
lab head | |
Prerana Wagle |
contact affiliation | CECAD Research Center |
contact email | proteomics-facility@uni-koeln.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD046388 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046388
- Label: PRIDE project
- Name: Proteomic analysis of pleomorphic dermal sarcoma