PXD046360 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Changes in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma |
Description | Low grade serous ovarian cancer (LGSC) is a rare subtype of ovarian cancer, characterized by a slow growth rate, resistance to current treatment regimens, multiple recurrences and poor survival. LGSC arise from serous borderline tumor (SBT), however the mechanism of transformation is poorly understood. To better understand the biology of serous ovarian tumors, we performed whole proteome profiling of LGSC, SBT and the more common high grade serous (HGSC) ovarian tumors. Proteins associated with the tumor microenvironment were differentially expressed between LGSC and SBT or HGSC. In particular, fibroblast activation protein (FAP), a protein expressed in cancer associated fibroblasts, is abundantly expressed in LGSC. Furthermore, Tregs and M2 macrophages are more abundant in the stroma of LGSC compared to SBT. Together these data suggest that the tumor microenvironment provides a supportive environment for LGSC tumorigenesis and progression, and that targeting the tumor microenvironment of LGSC may be a viable therapeutic strategy. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-15 |
AnnouncementXML | Submission_2024-08-15_03:23:53.084.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Gian Luca Negri |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-24 10:07:58 | ID requested | |
⏵ 1 | 2024-08-15 03:23:54 | announced | |
2 | 2024-10-22 06:55:14 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1002/path.6338; |
Vallejos R, Zhantuyakova A, Negri GL, Martin SD, Spencer SE, Thornton S, Leung S, Lynch B, Qin Y, Chow C, Liang B, Zdravko S, Douglas JM, Milne K, Mateyko B, Nelson BH, Howitt BE, Kommoss FK, Horn LC, Hoang L, Singh N, Morin GB, Huntsman DG, Cochrane D, Changes in the tumour microenvironment mark the transition from serous borderline tumour to low-grade serous carcinoma. J Pathol, 264(2):197-211(2024) [pubmed] |
Keyword List
submitter keyword: TMT, ovarian cancer,serous borderline tumor |
Contact List
Gregg Morin |
contact affiliation | Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. |
contact email | gmorin@bcgsc.ca |
lab head | |
Gian Luca Negri |
contact affiliation | Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. |
contact email | gnegri@bcgsc.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046360
- Label: PRIDE project
- Name: Changes in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma