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PXD046331-1

PXD046331 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies
DescriptionIndividual complexes of the mitochondrial oxidative phosphorylation system (OXPHOS) are not linked solely by their function, they also share dependencies at the maintenance/assembly level, where one complex depends on the presence of a different individual complex. Despite the relevance of this ‘interdependence’ behavior for mitochondrial diseases, its true nature remains elusive. To understand the mechanism that can explain this phenomenon, we examined the consequences of aberration of different OXPHOS complexes in human cells. We demonstrate here that complete disruption of each of OXPHOS complexes resulted in a decrease of complex I (cI) level and that the major reason for this is linked to downregulation of mitochondrial ribosomal proteins. We conclude that the secondary cI defect is due to mitochondrial protein synthesis attenuation, while the responsible signaling pathways could differ based on the origin of the OXPHOS defect.
HostingRepositoryPRIDE
AnnounceDate2024-07-16
AnnouncementXMLSubmission_2024-07-16_15:18:28.700.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMarek Vrbacky
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmethylthiolated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-23 10:55:16ID requested
12024-07-16 15:18:29announced
22024-10-22 06:50:37announced2024-10-22: Updated project metadata.
32025-02-18 05:58:05announced2025-02-18: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: integrated stress response,mitochondria, OXPHOS, complex I, mitochondrial protein synthesis, secondary deficiency, complex IV, complex V, mitochondrial translation, biogenesis interdependency
Contact List
Tomas Mracek
contact affiliationInstitute of Physiology of the Czech Academy of Sciences Laboratory of Bioenergetics
contact emailtomas.mracek@fgu.cas.cz
lab head
Marek Vrbacky
contact affiliationCzech Academy of Sciences
contact emailproteom.krc@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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