PXD046295-1
PXD046295 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Serum proteomic and metabolomic characterization in the progression of chronic hepatitis B-related hepatocellular carcinoma |
Description | Chronic hepatitis B Virus (HBV) infection induces multi-step changes in the liver, involving liver fibrosis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC) which is a deadly malignant tumor that lacks more effective diagnosis and treatment methods. Developing highly sensitive biomarkers could aid in early detection and intervention, improving survival rates. While numerous studies have analyzed HCC and healthy individuals, few have systematically studied HCC biomarkers from the perspective of progression changes. Here, we first constructed a comprehensive HCC-specific candidate biomarker bank, comprising up to 2968 proteins and 103 metabolites, based on the differentially expressed proteins identified by the current study, as well as HCC-related proteins and metabolites summarized from previous studies. We next determined the serum proteomics and metabolomics of 316 healthy controls and patients with HBV, HCV, LC and HCC, and constructed a cancerous trajectory of liver diseases using our DeepPRM targeted method. Based on and the machine learning-based computational pipeline, we found an 8-biomolecular based biomarker combination (accuracy rate: 91.43%) which can be used for the early diagnosis of HCC. Meanwhile, a 12-biomolecular based biomarker combination (accuracy rate: 80.00%) was identified for revealing the alterations in HBV–LC progression. This extensive circulating biomarker development study provides wealthy proteomic and metabolic data resources for better understanding of cancer biology processes in liver diseases. |
HostingRepository | iProX |
AnnounceDate | 2023-10-20 |
AnnouncementXML | Submission_2024-07-07_20:35:11.434.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yueting Xiong |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480; QTRAP 6500+ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-10-22 19:14:08 | ID requested | |
⏵ 1 | 2024-07-07 20:35:11 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: biomarker discovery / hepatocellular carcinoma / mass spectrometry / serum proteome profiling |
Contact List
Xiaohui Liu | |
---|---|
contact affiliation | Institutes of Biomedical Sciences, Fudan University |
contact email | liuxiaohui@fudan.edu.cn |
lab head | |
Yueting Xiong | |
contact affiliation | Xiamen University |
contact email | ytxiong@xmu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |