PXD046294-1

PXD046294 is an original dataset announced via ProteomeXchange.

Title	Protein expression signature in cell competition in HCC
Description	Although increasing studies have proved cell competition widely involved in the growth and homeostasis of multicellular organisms is closely linked to tumorigenesis and development, the mechanistic contributions between drug resistance and tumor cell competition remain ill-defined. In this paper, we applied MS of cell competition group to determine the dominant characteristics of lenvatinib resistance and its metabolic differences in cell competition. Our results showed a vital role of HSP90-IDH1 mediated lipid accumulation in maintaining the competitive outcome of HCC drug-resistant cells via regulating lipid metabolism. HSP90-IDH1 axis could be a promising target to overcome HCC drug resistance.
HostingRepository	iProX
AnnounceDate	2023-10-20
AnnouncementXML	Submission_2024-01-02_19:58:35.880.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sikai Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-22 19:09:02	ID requested
⏵ 1	2024-01-02 19:58:36	announced

Dataset with its publication pending

submitter keyword: HCC, Drug resistance, Cell competition

Sikai Wang
contact affiliation	Zhongshan Hospital, Fudan University
contact email	21211210072@m.fudan.edu.cn
lab head
Sikai Wang
contact affiliation	Zhongshan Hospital, Fudan University
contact email	21211210072@m.fudan.edu.cn
dataset submitter

iProX dataset URI