PXD046258-1

PXD046258 is an original dataset announced via ProteomeXchange.

Title	Fungal extract screening reveals malformin C to preferentially kill glioblastoma cells via concerted induction of proteotoxic stress and autophagic flux blockade
Description	Azide-labelled malformin C or DMSO was incubated with protein lysate from patient derived glioblastoma stem-like cells (NCH421k), and a pulldown of the compound with Dibenzocyclooctyne (DBCO) agarose was performed in order to identify interacting proteins.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_11:53:39.919.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emma Phillips
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-20 04:34:56	ID requested
⏵ 1	2025-05-06 11:53:40	announced

10.1002/1878-0261.13756;

Phillips E, van Enk S, Kildgaard S, Schlue S, G, ö, ttmann M, Jennings V, Bethke F, M, ü, ller G, Herold-Mende C, Pastor-Flores D, Schneider M, Helm D, Ostenfeld Larsen T, Goidts V, Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade. Mol Oncol, 19(3):785-807(2025) [pubmed]

submitter keyword: target deconvolution,Glioblastoma, stem cells

Violaine Goidts
contact affiliation	Junior Research Group “Brain Tumor Translational Targets”, German Cancer Research Center (DKFZ), Heidelberg, Germany
contact email	v.goidts@dkfz.de
lab head
Emma Phillips
contact affiliation	DKFZ
contact email	e.phillips@dkfz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD046258

PRIDE project URI

• PRIDE
  1. PXD046258
     1. Label: PRIDE project
     2. Name: Fungal extract screening reveals malformin C to preferentially kill glioblastoma cells via concerted induction of proteotoxic stress and autophagic flux blockade