PXD046234 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | New orphan disease therapies from the proteome of industrial plasma processing waste |
Description | Plasma-derived therapeutic proteins are produced through an industrial fractionation process where proteins are purified from individual intermediates, some of which remain unused and are discarded. Relatively few plasma-derived proteins are exploited clinically, with most of available plasma being directed towards the manufacture of immunoglobulin and albumin. Although the plasma proteome provides opportunities to develop novel protein replacement therapies, particularly for rare diseases, the high cost of plasma together with small patient populations impact negatively on the development of plasma-derived orphan drugs. Enabling therapeutics development from unused plasma fractionation intermediates would therefore constitute a significant innovation. To this objective, we characterized the proteome of unused plasma fractionation intermediates and prioritized proteins for their potential as new candidate therapies for human disease. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-23 |
AnnouncementXML | Submission_2024-01-23_09:12:16.904.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Vittoria Cicaloni |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-19 03:25:57 | ID requested | |
⏵ 1 | 2024-01-23 09:12:17 | announced | |
Publication List
Keyword List
submitter keyword: Plasma, LC-MS/MS |
Contact List
Laura Salvini |
contact affiliation | Mass Spectrometry Unit - Fondazione Toscana Life Sciences |
contact email | l.salvini@toscanalifesciences.org |
lab head | |
Vittoria Cicaloni |
contact affiliation | Fondazione Toscana Life Sciences |
contact email | v.cicaloni@toscanalifesciences.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046234
- Label: PRIDE project
- Name: New orphan disease therapies from the proteome of industrial plasma processing waste