PXD046142-1

PXD046142 is an original dataset announced via ProteomeXchange.

Title	Stable Isotope Labeling by Amino acid in Vivo (SILAV)
Description	Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in cerebrospinal fluid (CSF) and in plasma using targeted mass spectrometry (MS). This labeling approach could be of great interest for monitoring many leucine-containing peptides in parallel, using Mass Spectrometry. This will make it possible to quantify the rates of synthesis and clearance of a large range of proteins in humans with a view to obtaining new insights into protein metabolism processes and the pathophysiology of diseases such as Alzheimer's disease.
HostingRepository	PanoramaPublic
AnnounceDate	2025-11-15
AnnouncementXML	Submission_2025-11-15_20:22:12.269.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jerome VIALARET
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Label:13C(6)
Instrument	6490 Triple Quadrupole LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-15 15:37:46	ID requested
⏵ 1	2025-11-15 20:22:13	announced

Giroux P, Vialaret J, Kindermans J, Gabelle A, Bauchet L, Hirtz C, Lehmann S, Colinge J, . J Proteome Res, 23(7):2408-2418(2024) [pubmed]

submitter keyword: Protein turnover, human, Proteomics, SILK

Lehmann Sylvain
contact affiliation	Montpellier University
contact email	sylvain.lehmann@umontpellier.fr
lab head
Jerome VIALARET
contact affiliation	Montpellier University
contact email	jerome_vialaret@yahoo.fr
dataset submitter

Panorama Public dataset URI