PXD046110-1

PXD046110 is an original dataset announced via ProteomeXchange.

Title	Environmental Enrichment and Rat Liver Proteomics
Description	We aimed to address the challenge of accommodating an increasing demand for aged laboratory animals in the context of rising elderly population and research on aging-related diseases. We developed a cost-effective environmental enrichment method and assessed its impact on metabolic changes in Sprague Dawley rats' livers as a proof-of-concept organ. Twenty-four male rats were divided into four groups, with two kept in standard cages and two in modified rabbit cages. Half of each type of cage group received additional enrichment through weekly playtime in a larger cage. Over six months, the rats' weight gain was consistent across all groups, and corticosterone levels did not significantly differ. However, the control group had significantly lower DHEA and Testosterone levels at the study's end. Rats in enriched environments exhibited less distress during inspections and were more resistant to accepting treats. Animals accustomed to playpen time left their cages more easily. Overall, the study demonstrated that refining husbandry for aging rats is both simple and cost-effective, without detrimental effects on stress levels, development, or liver metabolism.
HostingRepository	PRIDE
AnnounceDate	2024-01-22
AnnouncementXML	Submission_2024-01-22_06:41:31.712.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simon Moosburner
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-13 03:51:27	ID requested
⏵ 1	2024-01-22 06:41:32	announced
2	2024-10-22 06:24:31	announced	2024-10-22: Updated project metadata.

10.1371/JOURNAL.PONE.0297497;

submitter keyword: Bile,Rat, Liver

Prof. Dr. Igor M. Sauer
contact affiliation	Experimental Surgery, Department of Surgery, Charité - Universitätsmedizin Berlin
contact email	igor.sauer@charite.de
lab head
Simon Moosburner
contact affiliation	Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Surgery, Berlin, Germany
contact email	simon.moosburner@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD046110

PRIDE project URI

• PRIDE
  1. PXD046110
     1. Label: PRIDE project
     2. Name: Environmental Enrichment and Rat Liver Proteomics