PXD046061 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Ketogenic diet versus standard high-carbohydrate nutrition in sepsis: a randomized controlled trial |
Description | Rationale: Sepsis patients suffer from severe metabolic and immunologic dysfunction that may be amplified by standard carbohydrate-based nutritional regimes. We therefore hypothesize that a ketogenic diet improves sepsis treatment. Objectives: We investigated the safety and feasibility of a ketogenic diet in sepsis patients. Methods: We conducted a monocentric open-labeled randomized controlled trial (DRKS00017710) enrolling adult sepsis patients randomly assigned to either ketogenic or standard high-carbohydrate diet for 14 days with follow-up until day 30. The primary outcome measure was β-hydroxybutyrate serum concentration on day 14. Secondary outcomes included safety, clinical and immunological changes. Measurements and Main Results: 40 critically ill septic patients were assigned to the study groups. Increase in β-hydroxybutyrate concentrations from baseline to day 14 was markedly greater under ketogenic diet (1.2 ±0.9) compared to controls (-0.3 ±0.4); estimated mean difference 1.4 (95%-CI 1.0-1.8; p<0.0001). During ketogenic diet, no patient required insulin treatment beyond day 4, whereas 35% to 60% of control patients did (p=0.0095). Metabolic side effects were not observed under ketogenic diet. Ventilation-free (IRR 1.7; 95%-CI: 1.5 to 2.1; p<0.0001), vasopressor-free (IRR 1.7; 95%-CI: 1.5 to 2.0; p<0.0001), dialysis-free (IRR 1.5; 95%-CI: 1.3 to 1.8; p<0.0001), and ICU-free days (IRR 1.7; 95%-CI: 1.4 to 2.1; p<0.0001) significantly increased in patients under ketogenic diet. There was no difference in 30-day mortality. Analyses indicated favorable changes towards immune homeostasis. Conclusions: Ketogenic diet is a feasible and safe nutritional regimen in septic patients promoting recovery from sepsis-related organ dysfunction and could become a new tool in modern treatment concepts. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-12 |
AnnouncementXML | Submission_2024-07-12_01:38:41.706.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Thilo Bracht |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-10-11 06:10:58 | ID requested | |
1 | 2024-06-13 01:27:54 | announced | |
⏵ 2 | 2024-07-12 01:38:42 | announced | 2024-07-12: Updated project metadata. |
Publication List
10.1126/scitranslmed.adn9285; |
Rahmel T, Effinger D, Bracht T, Griep L, Koos B, Sitek B, H, ü, bner M, Hirschberger S, Basten J, Timmesfeld N, Adamzik M, Kreth S, An open-label, randomized controlled trial to assess a ketogenic diet in critically ill patients with sepsis. Sci Transl Med, 16(755):eadn9285(2024) [pubmed] |
Keyword List
submitter keyword: nutritional medicine, inflammation, sepsis, intensive care, critically ill patients,Ketogenic diet |
Contact List
Prof. Dr. Barbara Sitek |
contact affiliation | Clinical Proteomics Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie & Medizinisches Proteom-Center, Ruhr-University Bochum |
contact email | barbara.sitek@rub.de |
lab head | |
Thilo Bracht |
contact affiliation | Clinical Proteomics |
contact email | thilo.bracht@rub.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046061
- Label: PRIDE project
- Name: Ketogenic diet versus standard high-carbohydrate nutrition in sepsis: a randomized controlled trial