PXD046058-2

PXD046058 is an original dataset announced via ProteomeXchange.

Title	Protein profiling of plasma extracellular vesicles from rheumatoid arthritis patients.
Description	Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation and cartilage/bone damage. Cytokines like IL-1 and TNF, play a crucial role in the pathophysiology of RA but have limited diagnostic and prognostic value. Recently, extracellular vesicles (EVs) have gained attention in the pathogenesis of this disease, but which processes they reflect in RA is unknown. Therefore, we identified and quantified proteins in plasma-derived EVs from RA patients (RA-pEVs) by mass spectrophotometry (MS) and compared these proteins to pEVs from healthy controls (HC). The observed RA-pEV proteins were coupled to clinical or laboratory parameters to investigate which RA disease process is reflecting by circulating EVs.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:17:28.279.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pascal Jansen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-11 05:44:11	ID requested
1	2023-12-13 05:19:06	announced
⏵ 2	2024-10-22 06:17:28	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Extracellular Vesicles,Proteomics, Plasma

Peter M. van der Kraan
contact affiliation	Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
contact email	peter.vanderkraan@Radboudumc.nl
lab head
Pascal Jansen
contact affiliation	Radboud University
contact email	p.jansen@science.ru.nl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD046058
     1. Label: PRIDE project
     2. Name: Protein profiling of plasma extracellular vesicles from rheumatoid arthritis patients.