PXD046051 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ultrasound-activated Piezoelectric Nanoparticles Trigger Microglia Activity against Glioblastoma Cells |
| Description | Glioblastoma multiforme (GBM) is the most aggressive brain cancer, characterized by a rapid and drug-resistant progression. GBM “builds” around its primary core a genetically heterogeneous tumor-microenvironment (TME), recruiting surrounding healthy brain cells by releasing various intercellular signals. Glioma-associated microglia (GAM) represent the largest population of collaborating cells, which, in the TME, usually exhibit the anti-inflammatory M2 phenotype, thus promoting an immunosuppressing environment that helps tumor growth. Conversely, “classically activated” M1 microglia could provide pro-inflammatory and anti-tumorigenic activity, expected to exert a beneficial effect in defeating glioblastoma. In this work, we developed a targeted anti-glioma immunotherapy, based on pro-inflammatory modulation of the GAM phenotype, through a controlled and localized electrical stimulation. The proposed strategy relies on the excitation through the remote application of ultrasound of polymeric piezoelectric nanoparticles, coated with GBM cell membrane extracts to allow homotypic targeting. Such camouflaged nanotransducers locally generate electrical cues on GAM membranes, ultimately activating their M1 phenotype, and thus triggering a significant anti-cancer activity. Collected findings open new perspectives in the modulation of immune cell activities though “smart” nanomaterials and, more specifically, provide an innovative tool in glioma immunotherapy. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-16 |
| AnnouncementXML | Submission_2026-07-16_01:34:22.409.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Martina Bartolucci |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-10-11 02:04:57 | ID requested | |
| ⏵ 1 | 2026-07-16 01:34:22 | announced | |
Publication List
Keyword List
| submitter keyword: Glioblastoma immunotherapy, Microglia activation,Piezoelectric nanoparticles, Homotypic camouflage |
Contact List
| Andrea Petretto |
|---|
| contact affiliation | IRCCS Istituto G Gaslini |
| contact email | a.petretto@mail.com |
| lab head | |
| Martina Bartolucci |
|---|
| contact affiliation | IRCCS Gaslini |
| contact email | smartibartolucci@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD046051 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD046051
- Label: PRIDE project
- Name: Ultrasound-activated Piezoelectric Nanoparticles Trigger Microglia Activity against Glioblastoma Cells
