PXD046041-1

PXD046041 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of human sperm protamines from men with and without infertility
Description	The objective of this study was to provide a comprehensive assessment of protamine isoforms and modifications in human sperm with the aim of identifying how protamine modifications/isoforms are altered in men with reduced sperm motility and low sperm count. Sperm samples from 18 men with prior reported pregnancy and normozoospermia 14 men from couples with infertility and asthenozoospermia and 24 men from couples with infertility and oligoasthenoteratozoospermia were included in the study. Proteomic assessment using both top-down and bottom-up LC-MS was performed.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_12:03:43.694.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD046041
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Samantha Schon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; phosphorylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-10 14:21:45	ID requested
⏵ 1	2025-05-06 12:03:44	announced

Publication List

10.1016/j.xfss.2023.12.002;
10.6019/PXD046041;
Schon SB, Moritz L, Rabbani M, Meguid J, Juliano BR, Ruotolo BT, Aston K, Hammoud SS, Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility. F S Sci, 5(2):121-129(2024) [pubmed]

10.1016/j.xfss.2023.12.002;

10.6019/PXD046041;

Schon SB, Moritz L, Rabbani M, Meguid J, Juliano BR, Ruotolo BT, Aston K, Hammoud SS, Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility. F S Sci, 5(2):121-129(2024) [pubmed]

Keyword List

submitter keyword: male-factor infertility, sperm,Protamines

submitter keyword: male-factor infertility, sperm,Protamines

Contact List

Samantha Schon
contact affiliation	University of Michigan
contact email	sschon@med.umich.edu
lab head
Samantha Schon
contact affiliation	University of Michigan
contact email	sschon@med.umich.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD046041
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD046041

PRIDE project URI

Repository Record List

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