PXD045836-2

PXD045836 is an original dataset announced via ProteomeXchange.

Title	Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation
Description	The crosstalk between the bone and adipose tissue orchestrates the metabolic homeostasis, but the underlying mechanisms are largely unknown. Herein, we find that GCA+(grancalcin) immune cells accumulate in the bone marrow and release a sufficient amount of GCA into circulation during obesity. Genetic deletion of Gca in myeloid cells attenuates metabolic dysfunction in obese male mice, whereas injection of recombinant GCA into male mice cause adipose tissue inflammation and insulin resistance. Mechanistically, we found that GCA binds to the Prohibitin-2 (PHB2) receptor on adipocytes and activates the innate and adaptive immune response of adipocytes via the PAK1-NF-κB signaling pathway, thus provoking the infiltration of inflammatory immune cells. Moreover, GCA-neutralizing antibodies improve adipose tissue inflammation and insulin sensitivity in obese male mice. Together, these observations uncover a novel mechanism whereby bone marrow factor GCA initiates adipose tissue inflammation and insulin resistance, implicating GCA could be a potential target to treat metainflammation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:13:40.158.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Su Tian
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-30 03:27:53	ID requested
1	2023-11-06 03:51:46	announced
⏵ 2	2024-10-22 06:13:40	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Grancalcin

insulin resistance

metabolic inflammation

Xianghang Luo
contact affiliation	Xiangya Hospital of Central South University
contact email	xianghangluo@csu.edu.cn
lab head
Su Tian
contact affiliation	xiangya hospital
contact email	251906072@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045836
     1. Label: PRIDE project
     2. Name: Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation