PXD045683-1
PXD045683 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Traceless peptide and protein modification via rational tuning of halopyridiniums |
| Description | Building on the insights gained from systematically investigating of aromatic nucleophilic substitution (SNAr) and thiol-exchange, we identified the highly electron-deficient halopyridiniums as a tunable and predictable reaction platform for adjusting electrophilicity and thiol-cleavability by following a positive Hammett correlation. This pyridinium-based platform was practical for both cleavable peptide stapling and protein functionalization. With this highly tunable and predictable toolkit, we successfully achieved GSH-response cleavable peptide stapling, antibody conjugation, enzyme masking/de-masking, and proteome labeling. Furthermore, the positively charged species exhibit improved cell-permeability and digestion-stability, making them attractive candidates for the manipulation of the functions and biophysical properties of biomolecules. |
| HostingRepository | iProX |
| AnnounceDate | 2023-09-25 |
| AnnouncementXML | Submission_2023-09-25_20:23:46.302.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rui Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-09-25 20:23:29 | ID requested | |
| ⏵ 1 | 2023-09-25 20:23:46 | announced | |
| 2 | 2024-05-21 00:51:59 | announced | 2024-05-21: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Halopyridinium modification, Protein profiling, Cleavable peptide stapling |
Contact List
| Rui Wang | |
|---|---|
| contact affiliation | Pingshan Translational Medicine Center, Shenzhen Bay Laboratory |
| contact email | wangrui@szbl.ac.cn |
| lab head | |
| Rui Wang | |
| contact affiliation | Pingshan Translational Medicine Center, Shenzhen Bay Laboratory |
| contact email | wangrui@szbl.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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