PXD045634-1

PXD045634 is an original dataset announced via ProteomeXchange.

Title	Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase
Description	G-quadruplexes (G4s) are noncanonical nucleic acid structures pivotal to cellular processes and disease pathways. Deciphering G4-interacting proteins is imperative for unraveling G4's biological significance. In this study, we developed a G4-targeting biotin ligase named G4PID, meticulously assessing its binding affinity and specificity both in vitro and in vivo. Capitalizing on G4PID, we devised a tailored approach termed G-quadruplex-interacting proteins specific biotin-ligation procedure (PLGPB) to precisely profile G4-interacting proteins.
HostingRepository	PRIDE
AnnounceDate	2024-05-24
AnnouncementXML	Submission_2024-05-24_01:00:39.687.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ziang Lu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-25 00:22:13	ID requested
⏵ 1	2024-05-24 01:00:40	announced

10.1093/nar/gkae126;

Lu Z, Xie S, Su H, Han S, Huang H, Zhou X, Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase. Nucleic Acids Res, 52(7):e37(2024) [pubmed]

submitter keyword: G-qudraplex interacting,human

Xiang Zhou
contact affiliation	College of Chemistry and Molecular Sciences. Wuhan University.
contact email	xzhou@whu.edu.cn
lab head
Ziang Lu
contact affiliation	Wuhan University
contact email	zianglu@whu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD045634

PRIDE project URI

• PRIDE
  1. PXD045634
     1. Label: PRIDE project
     2. Name: Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase