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PXD045626-2

PXD045626 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDIA proteomic of serum samples for the exploration of the pathological mechanism of Obstetric Antiphospholipid syndorme
DescriptionObstetric Antiphospholipid syndrome (OAPS) is a multisystem disorder characterized by thrombosis and/or recurrent fetal loss. In this study, we aim to further explore the pathological mechanism of OAPS. Herein, we carried out quantitative proteomic analysis of serum samples from OAPS patients and healthy controls to identify differentially expressed proteins between them. A data-independent Acquisition (DIA) mass spectrometry method for unbiased proteome profiling for the high sensitivity detection of clinical microsamples. A set of 93 proteins were differentially identified, including 75 up-regulated and 18 down-regulated proteins compared with the levels in controls. GO enrichment analysis showed that most of the differentially expressed proteins were located in extracellular region part, extracellular region and extracellular space, mainly involved in in biological processes such as response to chemical, response to organic substance and cellular response to chemical stimulus, and the main molecular functions are protein binding, receptor binding and identical protein binding. The most enriched KEGG pathways were autoimmune diseases and allergic diseases pathway, metabolic related pathways, pathogen infection pathways, and lysosome pathways. There were key nodes among the differentially expressed proteins including HLA-DRA,CRP and TNFSF13B. Our study formed a basis to perform new proteomic studies in OAPS to better understand the proteins involved in the pathogenesis of the syndrome and to provides the possibility to explore the pathogenesis of OAPS.
HostingRepositoryiProX
AnnounceDate2023-09-25
AnnouncementXMLSubmission_2024-05-21_00:52:42.642.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHaohao Tang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-24 19:26:09ID requested
12023-09-24 19:26:29announced
22024-05-21 00:52:43announced2024-05-21: Update information.
Publication List
Zhang Y, Jin S, Tian W, Shi D, Chen Y, Cui L, Zheng J, Proteomics of Serum Samples for the Exploration of the Pathological Mechanism of Obstetric Antiphospholipid Syndrome. J Proteome Res, 23(1):289-300(2024) [pubmed]
Keyword List
submitter keyword: proteomics, DIA, OAPS
Contact List
Yang Chen
contact affiliationPeking University Health Science Center, Peking University
contact emailchenyang1816185048@bjmu.edu.cn
lab head
Haohao Tang
contact affiliationPeking University Health Science Center, Peking University
contact emailTanghaohao0987@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI