PXD045612-1

PXD045612 is an original dataset announced via ProteomeXchange.

Title	Molecular fingerprint by omics-based approaches in saliva from patients affected by SARS-CoV-2 infection
Description	Clinical expression of COVID-19 infection is widely variable including fatal cases alongside a- or pauci-symptomatic cases with a rapid resolution. We studied saliva from 63 hospitalized COVID patients and from 30 healthy controls by integrating proteomics. peptidomics. and metabolomics to assess the biochemical alterations following the infection and to obtain a set of biomarkers useful for non-invasive diagnosis. We used LC-MS/MS for proteomic and peptidomic analysis and LC-MRM/MS for the analysis of amino acids. The levels of 77 proteins were significantly different in COVID patients. among which 14 proteins were found only in saliva from patients with COVID-19 (7 proteins) or were up-regulated (4 proteins) or down-regulated (3 proteins) at least 5 folds in saliva from COVID patients in comparison to controls. The analysis of proteins revealed a complex balance between pro-inflammatory and anti-inflammatory proteins. and a reduced amount of several proteins with immune activity that possibly favors the spreading of the virus.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_03:53:54.191.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anna Illiano
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-23 06:43:52	ID requested
⏵ 1	2024-10-17 03:53:55	announced

Pinto G, Gelzo M, Cernera G, Esposito M, Illiano A, Serpico S, Pinchera B, Gentile I, Castaldo G, Amoresano A, Molecular fingerprint by omics-based approaches in saliva from patients affected by SARS-CoV-2 infection. J Mass Spectrom, 59(9):e5082(2024) [pubmed]

10.1002/jms.5082;

submitter keyword: proteomics

peptides

metabolomics

amino acids

LC-MS/MS

Anna Illiano
contact affiliation	University of Naples Federico II
contact email	anna.illiano@unina.it
lab head
Anna Illiano
contact affiliation	Università Federico 2 Napoli
contact email	anna.illiano@unina.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD045612

PRIDE project URI

• PRIDE
  1. PXD045612
     1. Label: PRIDE project
     2. Name: Molecular fingerprint by omics-based approaches in saliva from patients affected by SARS-CoV-2 infection