PXD045519-2

PXD045519 is an original dataset announced via ProteomeXchange.

Title	Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men
Description	This prospective study aimed to discover biomarkers in seminal plasma that could be employed for a non-invasive differential diagnosis of OA/NOA in order to rationalize surgery recommendations and improve success rates. Using label-free LC-MS/MS, we compared the proteomes of seminal plasma samples from fertile men (HC, n=8) and infertile men diagnosed with 1) OA (n=7), 2) NOA with successful sperm retrieval (mixed atrophy, n=8), and 3) NOA without sperm retrieval (Sertoli cell-only phenotype, n=7).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:34:15.453.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-20 05:45:32	ID requested
1	2024-03-20 17:53:05	announced
⏵ 2	2024-10-22 06:34:15	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Azoospermia, seminal plasma, Diagnosis, Proteomics, Testicular failure, biomarker

Daniela Fietz
contact affiliation	Institute for Veterinary Anatomy, Justus Liebig University Giessen Frankfurter Strasse 98, 35392 Giessen, Germany
contact email	Daniela.Fietz@vetmed.uni-giessen.de
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD045519

PRIDE project URI

• PRIDE
  1. PXD045519
     1. Label: PRIDE project
     2. Name: Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men