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PXD045503-1

PXD045503 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification
Description	Platinum-based chemotherapy causes genetic damage and induces apoptosis in ovarian cancer cells. Enhancing the ability to resist platinum drug-induced DNA damage and apoptotic stress is critical for tumor cells to acquire drug resistance. Here, we found that Y-box binding protein 1 (YBX1) was highly expressed in platinum-resistant patient-derived organoids (PDOs) and was a crucial gene for alleviating platinum-induced stress and maintaining drug resistance characteristics in ovarian cancer cells.
HostingRepository	iProX
AnnounceDate	2023-09-19
AnnouncementXML	Submission_2025-06-03_20:03:03.626.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenjun Cheng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-19 19:46:38	ID requested
⏵ 1	2025-06-03 20:03:04	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: YBX1

Contact List

Wenjun Cheng
contact affiliation	The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
contact email	chengwenjun@jsph.org.cn
lab head
Wenjun Cheng
contact affiliation	The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
contact email	chengwenjun@jsph.org.cn
dataset submitter

Full Dataset Link List

iProX dataset URI