PXD045477

PXD045477 is an original dataset announced via ProteomeXchange.

Title	The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium
Description	Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). Moreover, we demonstrated that Lin28b in CAFs promoted growth of PDAC by inducing cytokine PCSK9’s production. Using an orthotopic mouse model of PDAC, we fouind that depletion of Lin28b in CAFs reduced tumor weight, highlighting the importance of Lin28b in PDAC stromal. Thus, our study shows that the Lin28b-Wnt5a axis plays a critical role in bidirectional crosstalk between pancreatic tumor epithelium and TME and results in a pro-‍tumorigenic contexture.
HostingRepository	iProX
AnnounceDate	2023-09-19
AnnouncementXML	Submission_2023-09-18_23:00:58.494.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhaoqi Shu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-18 23:00:43	ID requested
⏵ 1	2023-09-18 23:00:58	announced

Dataset with its publication pending

submitter keyword: cancer-associated fibroblasts (CAFs), pancreatic ductal adenocarcinoma (PDAC), Lin28b, Wnt5a, Pcsk9

Ying Zhao
contact affiliation	Peking University
contact email	zhaoying0812@bjmu.edu.cn
lab head
Zhaoqi Shu
contact affiliation	Peking University
contact email	443060358@qq.com
dataset submitter

iProX dataset URI