PXD045477
PXD045477 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium |
| Description | Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin28b in cancer-associated fibroblasts (CAFs). Moreover, we demonstrated that Lin28b in CAFs promoted growth of PDAC by inducing cytokine PCSK9’s production. Using an orthotopic mouse model of PDAC, we fouind that depletion of Lin28b in CAFs reduced tumor weight, highlighting the importance of Lin28b in PDAC stromal. Thus, our study shows that the Lin28b-Wnt5a axis plays a critical role in bidirectional crosstalk between pancreatic tumor epithelium and TME and results in a pro-tumorigenic contexture. |
| HostingRepository | iProX |
| AnnounceDate | 2023-09-19 |
| AnnouncementXML | Submission_2023-12-04_21:04:17.893.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhaoqi Shu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-09-18 23:00:43 | ID requested | |
| 1 | 2023-09-18 23:00:58 | announced | |
| ⏵ 2 | 2023-12-04 21:04:18 | announced | 2023-12-05: Update publication information. |
Publication List
| Shu Z, Fan M, Tu B, Tang Z, Wang H, Li H, Li H, Yuan M, Bai J, Huo S, Wang L, Zhu WG, Wang W, Liu X, Shu S, Zhao Y, The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium. Nat Commun, 14(1):6885(2023) [pubmed] |
Keyword List
| submitter keyword: cancer-associated fibroblasts (CAFs), pancreatic ductal adenocarcinoma (PDAC), Lin28b, Wnt5a, Pcsk9 |
Contact List
| Ying Zhao | |
|---|---|
| contact affiliation | Peking University |
| contact email | zhaoying0812@bjmu.edu.cn |
| lab head | |
| Zhaoqi Shu | |
| contact affiliation | Peking University |
| contact email | 443060358@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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