PXD045445-2

PXD045445 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Metabolic Roadmap to Nephrogenesis
Description	CKD and hypertension to impact a staggering 1.5 billion individuals within the next decade. Optimal fetal growth and development are outcomes of a delicate interplay between genetic and environmental factors. Nutrition emerges as a pivotal environmental determinant, orchestrating proper organogenesis. Malnutrition disrupts normal embryo development and potentially leads to chronic diseases in later life. Our understanding of the specific metabolic routes and their impact on kidney development is still elusive. Here, we used a multi-omics approach to study the importance of glucose metabolism to proper kidney development. We cultured E13.5 embryonic kidneys in the presence or absence of partial inhibition of glycolysis and submitted it to transcriptomic and proteomic profiling. We found that glycolysis-derived acetyl-CoA is an intracellular pleiotropic agent pivotal for proper kidney development.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:03:28.250.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD045445
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jennifer Klein
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-18 04:00:51	ID requested
1	2023-09-18 13:50:43	announced
⏵ 2	2024-10-22 06:03:28	announced	2024-10-22: Updated project metadata.

Publication List

10.6019/PXD045445;

10.6019/PXD045445;

Keyword List

submitter keyword: Metabolism, Diet, glycolysis
mitochondria,kidney
Nephron progenitor cells, Proteomics

submitter keyword: Metabolism, Diet, glycolysis

mitochondria,kidney

Nephron progenitor cells, Proteomics

Contact List

Giovane G Tortelote
contact affiliation	Assistant Professor of Pediatrics Tulane University School of Medicine New Orleans, LA United States
contact email	gtortelote@tulane.edu
lab head
Jennifer Klein
contact affiliation	LSUHSC
contact email	jklei1@lsuhsc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD045445
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD045445

PRIDE project URI

Repository Record List

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