<<< Full experiment listing

PXD045355-1

PXD045355 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of ciliary protein interactome during senescence
DescriptionDespite the importance of cellular senescence in human health, how damaged cells undergo senescence remains vague. We have previously shown that the translocation of a ciliary protein FBF1 to nucleus is essential for senescence induction in stressed cells. However, how dose FBF1 translocate from ciliary base to the nucleus still unclear. We employed BioID analysis to identify the potential interactor of FBF1 and associated protein that regulate FBF1 translocation. We discovered the ciliary base protein, CENEXIN1(ODF2), as interactor by using FBF1 as prey. We also explored CENEXIN1 (ODF2)interactome by APEX2-based BioID to idenfity KIFC3, a minus-end-directed kinesin, as downstream player that regulate the ciliary protein translocation.
HostingRepositoryPRIDE
AnnounceDate2024-08-19
AnnouncementXMLSubmission_2024-08-19_13:10:46.518.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD045355
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterJielu Robichaud
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListbiotinylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-13 07:54:42ID requested
12024-08-19 13:10:46announced
Publication List
10.6019/PXD045355;
Keyword List
submitter keyword: primary cilia, senescence
Contact List
Jinghua Hu
contact affiliationDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
contact emailHu.Jinghua@mayo.edu
lab head
Jielu Robichaud
contact affiliationMayo Clinic
contact emailhao.jielu@mayo.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD045355
PRIDE project URI
Repository Record List
[ + ]