PXD045338-1
PXD045338 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Interplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans |
| Description | Lysine acetylation and ubiquitination are one of many protein modifications and play a crucial role in the biological regulation of many organisms, but little is known about the relationship between acetylation and ubiquitination few. Here, the Isw1 protein is an important member of the chromatin remodeling complex, and we performed single-protein modification mass spectrometry detection of the C. neoformans Isw1 protein and site mutations for both detected modifications. The data showed that the two modifications of Cryptococcus neoformans Isw1 protein have a balance of each other. Acetylation can maintain protein stability and maintain protein function, while ubiquitination can reduce protein level and maintain Isw1 protein expression. The expression level of Isw1 protein leads to resistance to antifungal drugs. These results reveal the resistance mechanism of Isw1 protein of Cryptococcus neoformans to antifungal drugs. |
| HostingRepository | iProX |
| AnnounceDate | 2023-09-13 |
| AnnouncementXML | Submission_2023-09-12_22:06:45.491.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yang Meng |
| SpeciesList | scientific name: Cryptococcus neoformans var. grubii H99; NCBI TaxID: 235443; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-09-12 22:06:22 | ID requested | |
| ⏵ 1 | 2023-09-12 22:06:45 | announced | |
| 2 | 2024-02-27 18:32:31 | announced | 2024-02-28: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: acetylation, ubiquitination, multidrug resistance |
Contact List
| Yang Meng | |
|---|---|
| contact affiliation | College of Life and Health Sciences, Northeastern University |
| contact email | MMMyang0130@163.com |
| lab head | |
| Yang Meng | |
| contact affiliation | College of Life and Health Sciences, Northeastern University, Shenyang, China. |
| contact email | MMMyang0130@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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