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PXD045338 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInterplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans
DescriptionLysine acetylation and ubiquitination are one of many protein modifications and play a crucial role in the biological regulation of many organisms, but little is known about the relationship between acetylation and ubiquitination few. Here, the Isw1 protein is an important member of the chromatin remodeling complex, and we performed single-protein modification mass spectrometry detection of the C. neoformans Isw1 protein and site mutations for both detected modifications. The data showed that the two modifications of Cryptococcus neoformans Isw1 protein have a balance of each other. Acetylation can maintain protein stability and maintain protein function, while ubiquitination can reduce protein level and maintain Isw1 protein expression. The expression level of Isw1 protein leads to resistance to antifungal drugs. These results reveal the resistance mechanism of Isw1 protein of Cryptococcus neoformans to antifungal drugs.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYang Meng
SpeciesList scientific name: Cryptococcus neoformans var. grubii H99; NCBI TaxID: 235443;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-09-12 22:06:22ID requested
12023-09-12 22:06:45announced
22024-02-27 18:32:31announced2024-02-28: Update information.
Publication List
Meng Y, Ni Y, Li Z, Jiang T, Sun T, Li Y, Gao X, Li H, Suo C, Li C, Yang S, Lan T, Liao G, Liu T, Wang P, Ding C, . Elife, 13():(2024) [pubmed]
Keyword List
submitter keyword: acetylation, ubiquitination, multidrug resistance
Contact List
Yang Meng
contact affiliationCollege of Life and Health Sciences, Northeastern University
contact emailMMMyang0130@163.com
lab head
Yang Meng
contact affiliationCollege of Life and Health Sciences, Northeastern University, Shenyang, China.
contact emailMMMyang0130@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI