PXD045319 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Apolipoprotein E is associated with dense deposits in dense deposit disease |
Description | C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway (AP) of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Both C3GN and DDD are characterized by bright glomerular C3 staining on immunofluorescence studies. However, on electron microscopy, DDD is characterized by dense osmiophilic mesangial and intramembranous deposits along the glomerular basement membranes (GBM), while the deposits of C3GN are not dense. Why the deposits appear dense in DDD and not in C3GN is not known.We performed laser microdissection of glomeruli followed by mass spectrometry in 12 known cases of DDD and C3GN each to determine the proteomic profile and differences between C3GN and DDD. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_08:14:33.031.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD045319 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Benjamin Madden |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF; Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-12 11:50:52 | ID requested | |
⏵ 1 | 2024-10-22 08:14:33 | announced | |
Publication List
Madden B, Singh RD, Haas M, Palma LMP, Sharma A, Vargas MJ, Gross L, Negron V, Nate T, Charlesworth MC, Theis JD, Nasr SH, Nath KA, Fervenza FC, Sethi S, Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy. Kidney Int, 105(5):1077-1087(2024) [pubmed] |
10.6019/PXD045319; |
10.1016/j.kint.2024.02.013; |
Keyword List
submitter keyword: Human, tandem mass spectrometry, kidney, LCM, glomeruli |
Contact List
Sanjeev Sethi |
contact affiliation | Anatomic Pathology, mayo clinic |
contact email | Sethi.sanjeev@mayo.edu |
lab head | |
Benjamin Madden |
contact affiliation | Mayo Clinic |
contact email | madden.benjamin@mayo.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045319
- Label: PRIDE project
- Name: Apolipoprotein E is associated with dense deposits in dense deposit disease