PXD045301-1

PXD045301 is an original dataset announced via ProteomeXchange.

Title	Skeletal muscle proteome analysis of Inuit homozygous carriers of the common Greenlandic TBC1D4 p.Arg684Ter variant
Description	In the Greenlandic Inuit population, 17% are carriers of a nonsense TBC1D4 p.Arg684Ter variant. Homozygous variant carriers have impaired glucose tolerance and a 10-fold increased risk of type 2 diabetes. Here, we illuminate the consequences of lacking this muscle-specific long isoform of TBC1D4 during metabolic challenges in humans.
HostingRepository	PRIDE
AnnounceDate	2024-10-26
AnnouncementXML	Submission_2024-10-26_11:31:20.343.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sean Humphrey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-12 05:19:48	ID requested
⏵ 1	2024-10-26 11:31:20	announced

Dataset with its publication pending

submitter keyword: LC-MSMS, skeletal muscle,Muscle, proteome

Sean Humphrey
contact affiliation	Department of Stem Cell Medicine, Murdoch Children's Research Institute, Victoria, Australia
contact email	sean.humphrey@mcri.edu.au
lab head
Sean Humphrey
contact affiliation	Murdoch Children's Research Institute
contact email	sean.j.humphrey@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD045301

PRIDE project URI

• PRIDE
  1. PXD045301
     1. Label: PRIDE project
     2. Name: Skeletal muscle proteome analysis of Inuit homozygous carriers of the common Greenlandic TBC1D4 p.Arg684Ter variant