PXD045276 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Analysis Reveals Trilaciclib-Induced Senescence |
Description | Trilaciclib, a CDK4/6 inhibitor, was approved as a myeloprotective agent for extensive-stage small cell lung cancer in 2021. It achieves this by inducing a temporary cell cycle arrest in bone marrow cells. While it has been studied in various cancer types, its potential in haematological cancers remains unexplored. This research aimed to investigate the efficacy of trilaciclib in haematological cancers. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-16 |
AnnouncementXML | Submission_2024-06-15_23:58:07.660.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Matthias Trost |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | carbamoylated residue |
Instrument | Q Exactive HF; Bruker Daltonics timsTOF series |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-09-11 12:34:59 | ID requested | |
⏵ 1 | 2024-06-15 23:58:08 | announced | |
Publication List
Hermosilla-Trespaderne M, Hu-Yang MX, Dannoura A, Frey AM, George AL, Trost M, Mar, í, n-Rubio JL, Proteomic Analysis Reveals Trilaciclib-Induced Senescence. Mol Cell Proteomics, 23(6):100778(2024) [pubmed] |
10.1016/j.mcpro.2024.100778; |
Keyword List
submitter keyword: proteomics, resistance, trilaciclib, leukaemia, senescence |
Contact List
Matthias Trost |
contact affiliation | Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom |
contact email | matthias.trost@newcastle.ac.uk |
lab head | |
Matthias Trost |
contact affiliation | Newcastle University |
contact email | matthias.trost@ncl.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD045276 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD045276
- Label: PRIDE project
- Name: Proteomic Analysis Reveals Trilaciclib-Induced Senescence