PXD045194-1

PXD045194 is an original dataset announced via ProteomeXchange.

Title	Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer
Description	Spheroid formation during epithelial ovarian cancer progression correlates with peritoneal organ colonization, disease recurrence, and poor prognosis. Although cancer progression has been demonstrated to be associated with and driven by metabolic changes within transformed cells, possible associations between metabolic dynamics and metastatic morphological transitions remain unexplored. To address this problem, performed quantitative proteomics was performed to identify protein signatures associated with three distinct morphologies (2D monolayers and two geometrically individual three-dimensional spheroidal states) of the high-grade serous ovarian cancer line OVCAR-3. Integrating the protein states into genome-scale metabolic models allowed the construction of context-specific metabolic models for each morphological stage of the OVCAR-3 cell line and systematically evaluate their metabolic functionalities.
HostingRepository	PRIDE
AnnounceDate	2023-09-07
AnnouncementXML	Submission_2023-09-07_07:39:24.073.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	gaganjhingan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-07 07:17:17	ID requested
⏵ 1	2023-09-07 07:39:24	announced
2	2024-10-22 06:02:48	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: OVCAR-3, ovarian cancer,Genome-scale metabolic models, oseltamivir, morphological transitions, drug repurposing

Prof. RamrayBhat
contact affiliation	Associate Professor, Centre for Biosystems Science and Engineering, IISC Bangalore, India
contact email	ramray@iisc.ac.in
lab head
gaganjhingan
contact affiliation	VProteomics
contact email	gaganjhingan@hotmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD045194
     1. Label: PRIDE project
     2. Name: Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer