PXD045090-1

PXD045090 is an original dataset announced via ProteomeXchange.

Title	DIA proteomics reveals the regulatory process of Sacubitril in the treatment of myocardial infarction reperfusion
Description	As one of the major cardiovascular diseases, myocardial infarction is the most serious manifestation of coronary artery disease, which has attracted wide attention due to its high morbidity and mortality. The left anterior descending artery(LAD) of 6-8 weeks old male KM mice was ligated for 40min, followed by perfusion to establish an ischemia-reperfusion(I/R) model. After 3 days of monitoring, 60 mg/kg sacubitril/valsartan sodium was given for a week. Hematoxylin-eosin(HE) staining, 2, 3, 5-triphenyl-tetrazolium chloride(TTC) staining and echocardiography were used to evaluate the therapeutic effect of sacubitril/valsartan sodium on I/R.The proteomics information of heart tissue was obtained by data-independent acquisition(DIA) proteomics. The analysis results showed that sacubitril/valsartan sodium may mediate the treatment of I/R injury by regulating enzyme activity and immune-related biological processes, up-regulating fatty acid degradation metabolic pathway, PPAR pathway, peroxisome pathway, and down-regulating complement system and ribosome pathway.The results showed that sacubitril/valsartan sodium had a good therapeutic effect on I/R injury.
HostingRepository	iProX
AnnounceDate	2023-09-04
AnnouncementXML	Submission_2023-09-04_19:04:57.903.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xia Chen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-04 19:04:36	ID requested
⏵ 1	2023-09-04 19:04:58	announced

Dataset with its publication pending

submitter keyword: Myocardial infarction, Sacubitril/valsartan sodium,Ischemia-reperfusion,DIA proteomics

Xia Chen
contact affiliation	Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University
contact email	chenxia6@yeah.net
lab head
Xia Chen
contact affiliation	Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University
contact email	chenxia6@yeah.net
dataset submitter

iProX dataset URI