PXD045001-1

PXD045001 is an original dataset announced via ProteomeXchange.

Title	Proteome-wide discovery of human brain protein glycoforms and glycan modification changes in Alzheimer’s disease
Description	We performed a large-scale, intact glycopeptide-based glycoproteomics study of human brain tissue samples from neuropathologically confirmed AD cases and their age-matched controls. The study provided a system-level view of human brain protein glycoforms and site-specific glycan modifications. Our analyses revealed previously unknown changes in protein glycoforms and site-specific glycans in AD brain. Our findings provide novel insights into the roles of glycan modifications in brain dysfunction in AD.
HostingRepository	PRIDE
AnnounceDate	2024-04-08
AnnouncementXML	Submission_2024-04-08_06:56:36.364.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	QI ZHANG
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deaminated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-31 06:33:13	ID requested
⏵ 1	2024-04-08 06:56:36	announced

10.1126/SCIADV.ADK6911;

submitter keyword: mass spectrometry, intact glycopeptide-based glycoproteomics,Alzheimer's disease

Lian Li
contact affiliation	Department of Pharmacology and Chemical Biology Emory University School of Medicine Atlanta, GA, U.S.
contact email	lli5@emory.edu
lab head
QI ZHANG
contact affiliation	Emory University
contact email	QZHAN50@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD045001

PRIDE project URI

• PRIDE
  1. PXD045001
     1. Label: PRIDE project
     2. Name: Proteome-wide discovery of human brain protein glycoforms and glycan modification changes in Alzheimer’s disease