PXD044976-1

PXD044976 is an original dataset announced via ProteomeXchange.

Title	Adaptation-dependent alterations in the human skeletal muscle proteome and phosphoproteome of human skeletal muscle in response to damaging resistance exercise
Description	Resistance exercise (RE) enhances strength, muscle mass, and overall health. Intense RE also triggers rapid muscle damage that is efficiently restored through proteostatic mechanisms in healthy individuals. However, the specific factors and signalling processes active at sites of damage remain poorly understood. In this study, human subjects underwent acute, recurring, and interrupted high-intensity RE to induce, adapt, and deadapt skeletal muscle. Muscle biopsies were taken at thee time points to analyse the skeletal muscle proteome's localization and phosphorylation under these conditions. RE-induced lesions were reduced through continued training but quickly reestablished upon detraining.
HostingRepository	PRIDE
AnnounceDate	2026-04-28
AnnouncementXML	Submission_2026-04-28_14:43:20.223.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pitter Huesgen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-30 09:53:49	ID requested
⏵ 1	2026-04-28 14:43:20	announced

Dataset with its publication pending

submitter keyword: resistance exercise, proteomics, adaptation, fractionation,Human muscle, phosphoproteomics, deadaptation

Pitter Huesgen
contact affiliation	Faculty of Biology, University of Freiburg
contact email	pitter.huesgen@biologie.uni-freiburg.de
lab head
Pitter Huesgen
contact affiliation	University of Freiburg Faculty of Biology Biochemistry and Functional Proteomics
contact email	pitter.huesgen@biologie.uni-freiburg.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD044976
     1. Label: PRIDE project
     2. Name: Adaptation-dependent alterations in the human skeletal muscle proteome and phosphoproteome of human skeletal muscle in response to damaging resistance exercise