PXD044959-1

PXD044959 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	0N4R Tau and 0N4R Tau P301L Neuronal Interactomes
Description	Human non-mutated 0N4R Tau and P301L mutant 0N4R Tau tagged at the N-terminus with eGFP were expressed in mouse (CD1) primary cortical neurons using adeno associated viruses to monitor early changes in the synaptic interactome beforethe onset of neuronal loss. Affinity purification mass spectrometry (AP-MS) combined with tandem mass tagging was used to quantitatively compate the non-mutated and P301L interactomes.
HostingRepository	PRIDE
AnnounceDate	2024-07-03
AnnouncementXML	Submission_2024-07-03_01:57:13.170.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Robert Williams
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-30 05:25:17	ID requested
⏵ 1	2024-07-03 01:57:14	announced
2	2024-10-22 06:48:22	announced	2024-10-22: Updated project metadata.

Publication List

Hole KL, Zhu B, Huggon L, Brown JT, Mason JM, Williams RJ, disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability. Cell Death Dis, 15(6):429(2024) [pubmed]
10.1038/s41419-024-06815-2;

Hole KL, Zhu B, Huggon L, Brown JT, Mason JM, Williams RJ, disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability. Cell Death Dis, 15(6):429(2024) [pubmed]

10.1038/s41419-024-06815-2;

Keyword List

submitter keyword: Mouse Neurons,Human Tau, Tau, Synapse, P301L Mutation

submitter keyword: Mouse Neurons,Human Tau, Tau, Synapse, P301L Mutation

Contact List

Robert Justin Williams
contact affiliation	Department of Life Sciences, University of Bath, UK
contact email	r.j.williams@bath.ac.uk
lab head
Robert Williams
contact affiliation	University of Bath
contact email	r.j.williams@bath.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD044959
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD044959

PRIDE project URI

Repository Record List

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