PXD044941 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Host-defence peptide caerin 1.1 and 1.9 inhibited the proliferation of glioblastoma cells |
Description | Glioblastoma, the most aggressive form of brain cancer, remains a significant global contributor to mortality. Predictions of its increasing incidence in the coming decades underscore the need for more effective treatment strategies. Caerin 1.1 and 1.9, host defence peptides originally isolated from the skin secretions of an Australian tree frog, have exhibited tumour growth inhibition against a diverse spectrum of tumours in vitro. In this study, we reaffirm their potential by demonstrating their inhibitory impact on glioblastoma growth through CCK8 assays. Furthermore, caerin 1.1 and 1.9 effectively curtailed the migration of all tested glioblastoma cells in a cell scratch assay.Quantitative proteomic analysis was employed to investigate the molecular mechanism underlying the anti-proliferative activity. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-08 |
AnnouncementXML | Submission_2024-06-08_03:17:30.678.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tianfang Wang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-29 15:28:25 | ID requested | |
⏵ 1 | 2024-06-08 03:17:31 | announced | |
Publication List
Keyword List
submitter keyword: glioblastoma,caerin peptide, apoptosis, LC-MS/MS |
Contact List
Tianfang Wang |
contact affiliation | Centre for Bioinnovation, University of the Sunshine Coast |
contact email | twang@usc.edu.au |
lab head | |
Tianfang Wang |
contact affiliation | University of the Sunshine Coast |
contact email | twang@usc.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044941
- Label: PRIDE project
- Name: Host-defence peptide caerin 1.1 and 1.9 inhibited the proliferation of glioblastoma cells