PXD044912 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | A Cytotoxic T Cell Inspired Oncolytic Nanosystem Promotes Lytic Cell Death by Lipid Peroxidation And Elicits Antitumor Immune Responses |
Description | Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic cell death by several mechanisms. Moreover, a prolonged uncontrolled immune response conversely leads to T-cell exhaustion. Therefore, an oncolytic system capable of eliciting the immune response by dissolving cancer cells in a controlled manner is needed. Here, we establish a micro-scale cytotoxic T-cell-inspired oncolytic system (TIOs) to precisely lyse cancer cells by NIR-light-controlled lipid peroxidation. Our TIOs present antigen-based cell recognition, tumour-targeting and catalytic cell-lysis ability; thus, the TIOs induce oncolysis in vivo. We applied TIOs to antitumour therapies, which shows kinds of tumour models are cleared efficiently with negligible side-effects. Tumour regression is correlated with a T-cell based anti-tumour immune response and can be synergistic with anti-PD-1 therapy or STING activation. Our study provides new insights to design the oncolytic systems for antitumour immunity. Moreover, activation of STING can reverse T-cell exhaustion in oncolysis. |
HostingRepository | PRIDE |
AnnounceDate | 2023-09-05 |
AnnouncementXML | Submission_2023-09-04_18:32:17.847.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | haoyin |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-28 09:30:56 | ID requested | |
⏵ 1 | 2023-09-04 18:32:18 | announced | |
2 | 2023-11-14 07:11:26 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Lipid Peroxidation,Mouse, Antitumor Immune |
Contact List
haoyin |
contact affiliation | Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China. |
contact email | yinhao@wmu.edu.cn |
lab head | |
haoyin |
contact affiliation | Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China. |
contact email | yinhao@wmu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044912
- Label: PRIDE project
- Name: A Cytotoxic T Cell Inspired Oncolytic Nanosystem Promotes Lytic Cell Death by Lipid Peroxidation And Elicits Antitumor Immune Responses