PXD044911-1

PXD044911 is an original dataset announced via ProteomeXchange.

Title	pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy
Description	Tumour-associated macrophages (TAMs), as one of the most abundant and phagocytic tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune suppression. M2-like TAMs present a heightened lysosomal acidity and protease activity, which limits the function of antigen cross-presentation. How to selectively reprogram the antigen-destroying TAMs to a restorative phenotype for efficient anti-tumour immunity is challenging. Here, we report a pH-gated nanoadjuvant (PGN) that selectively targets the lysosomes of M2-like TAMs in tumours rather than the corresponding organelles from macrophages in healthy tissues. Enabled by the PGN nanotechnology, M2-like TAMs are specifically switched to M1-like phenotypes with tuned-down lysosomal function featured by attenuated lysosomal acidity and cathepsin activity for improved antigen cross-presentation, thus provoking adaptive immune response and sustained tumour regression. Our findings provide new insights into how to specifically regulate lysosomal function of TAMs for efficient cancer immunotherapy.
HostingRepository	PRIDE
AnnounceDate	2023-08-29
AnnouncementXML	Submission_2023-08-28_17:28:35.838.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TangMingmei
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-28 09:10:27	ID requested
⏵ 1	2023-08-28 17:28:36	announced

Dataset with its publication pending

submitter keyword: tumour-associated macrophages

Tangmingmei
contact affiliation	Wang Yiguang lab
contact email	mingmeitang@bjmu.edu.cn
lab head
TangMingmei
contact affiliation	Peking University
contact email	mingmeitang@bjmu.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD044911
     1. Label: PRIDE project
     2. Name: pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy