PXD044908-1

PXD044908 is an original dataset announced via ProteomeXchange.

Title	The Impact of Cycling Hypoxia on the Phenotype of HPV-Positive Cervical Cancer Cells
Description	Tumor hypoxia affects the aggressiveness and therapy response in solid tumors, including HPV-positive cancers. Cycling hypoxia, characterized by recurrent fluctuations in oxygen supply, is a prevalent, but much less investigated form of tumor hypoxia, and has been associated with a particularly therapy-resistant cancer cell subpopulation. Using mass spectrometry-based quantitative proteome analyses, we compare SiHa cells cultivated under normoxia (21% O2), physoxia (5.5% O2), chronic hypoxia (1% O2) and cycH (repeated cycles of 1 h at 1% O2 and 1 h at 5.5% O2) and assess distinct effects of cycH on the phenotype of HPV-positive cervical cancer cells.
HostingRepository	PRIDE
AnnounceDate	2023-12-07
AnnouncementXML	Submission_2023-12-07_07:12:01.245.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bianca Kuhn
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Human papillomavirus type 16; NCBI TaxID: 333760;
ModificationList	carbamoylated residue; monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-28 07:34:36	ID requested
⏵ 1	2023-12-07 07:12:01	announced
2	2024-01-24 15:03:53	announced	2024-01-24: Updated project metadata.
3	2024-10-22 06:16:56	announced	2024-10-22: Updated project metadata.

10.1002/JMV.29280;

submitter keyword: human papillomavirus (HPV), hypoxia, BH3 interacting domain death agonist (BID), Cisplatin (CDDP),cervical cancer, chemoresistance

Felix Hoppe-Seyler
contact affiliation	Molecular Therapy of Virus-Associated Cancers, German Cancer Research Center (DKFZ), Heidelberg, Germany.
contact email	hoppe-seyler@dkfz.de
lab head
Bianca Kuhn
contact affiliation	Broad Institute of MIT and Harvard
contact email	bkuhn@broadinstitute.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD044908

PRIDE project URI

• PRIDE
  1. PXD044908
     1. Label: PRIDE project
     2. Name: The Impact of Cycling Hypoxia on the Phenotype of HPV-Positive Cervical Cancer Cells