PXD044838-1

PXD044838 is an original dataset announced via ProteomeXchange.

Title	Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition.
Description	We utilize hydrogen deuterium exchange mass spectrometry (HDX-MS) to probe the solvation and conformational dynamics of HLA-A*01:01/hβ2m complexes that are emptied or loaded with NRAS Q61K peptide, as well as wild-type (Q61) and three additional, common neoepitopes (Q61H, Q61L, Q61R).
HostingRepository	PRIDE
AnnounceDate	2023-11-30
AnnouncementXML	Submission_2023-11-30_14:40:08.104.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Sun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-24 17:32:00	ID requested
⏵ 1	2023-11-30 14:40:08	announced

10.1038/S41467-023-43654-9;

submitter keyword: NRAS,HDX-MS

Nikolaos Sgourakis
contact affiliation	Children's Hospital of Phildelphia and University of Pennsylvania
contact email	Nikolaos.Sgourakis@pennmedicine.upenn.edu
lab head
Yi Sun
contact affiliation	University of Pennsylvania/Children's Hospital of Philadelphia
contact email	Yi.Sun1@Pennmedicine.upenn.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD044838

PRIDE project URI

• PRIDE
  1. PXD044838
     1. Label: PRIDE project
     2. Name: Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition.