PXD044802-1

PXD044802 is an original dataset announced via ProteomeXchange.

Title	Engineered skin microbiome-assisted delivery to the pilosebaceous unit
Description	Microbes are fascinating molecular machines which can be equipped with synthetic genetic programs that allow them to produce therapeutic molecules targeted on demand upon disease sensing. Cutibacterium acnes engraftment capacity and its living habitat close to important pharmacological targets makes it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium, the most abundant commensal of the human skin, to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin in vivo, known to modulate cutaneous sebum production.
HostingRepository	PRIDE
AnnounceDate	2023-11-10
AnnouncementXML	Submission_2023-11-10_08:51:29.850.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	EduardSabidó
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-23 09:08:57	ID requested
⏵ 1	2023-11-10 08:51:30	announced

Dataset with its publication pending

submitter keyword: Cutibacterium acnes,microbiome, engineering

EduardSabido
contact affiliation	Centre for Genomic Regulation, Universitat Pompeu Fabra
contact email	eduard.sabido@crg.cat
lab head
EduardSabidó
contact affiliation	Centre de Regulació Genòmica
contact email	eduard.sabido@crg.cat
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD044802

PRIDE project URI

• PRIDE
  1. PXD044802
     1. Label: PRIDE project
     2. Name: Engineered skin microbiome-assisted delivery to the pilosebaceous unit