PXD044780-2

PXD044780 is an original dataset announced via ProteomeXchange.

Title	A synthetic lethal strategy to target chromosome 8p deleted cancers
Description	This project aimed to identify a specific target for chromosome 8p deletions. Using large-scale functional-genomic screening data of over 527 well-characterized cancer cell lines. We were able to identify the dependency of SLC25A28 (Mitoferrin-2, MFRN2), a mitochondrial iron transporter, in chromosome 8p deleted cancer cell lines. Interestingly, we found that SLC25A37 (Mitoferrin-1, MFRN1), the paralog of MFRN2, resides on chromosome 8p and is frequently deleted in liver cancer. We found a strong correlation between the cellular dependency on MFRN2 and the MFRN1 expression levels, possibly explaining why MFRN2 is a synthetic lethal target for 8p deletions. Our study discovered MFRN2 as a target for a therapeutic strategy in chromosome 8p deleted cancer specimens. Further, it revealed MFRN1 as a biomarker that predicts the response to MFRN2-directed therapy.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:43:35.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Darjus Tschaharganeh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-08-23 02:08:54	ID requested
1	2024-06-03 02:43:18	announced
⏵ 2	2024-10-22 06:43:35	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Synthetic lethality,Mitoferrin-1, MFRN2, MFRN1, Mitoferrin-2

Darjus Tschaharganeh
contact affiliation	Cell Plasticity and Epigenetic Remodeling (F190) Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg
contact email	d.tschaharganeh@dkfz-heidelberg.de
lab head
Darjus Tschaharganeh
contact affiliation	German Cancer Research Center
contact email	d.tschaharganeh@dkfz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD044780

PRIDE project URI

• PRIDE
  1. PXD044780
     1. Label: PRIDE project
     2. Name: A synthetic lethal strategy to target chromosome 8p deleted cancers