PXD044777 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | De-obstruction of bladder outlet in humans reverses organ remodeling |
Description | Bladder outlet obstruction (BOO) causes lower urinary tract symptoms and objectifiable urodynamic changes in bladder function. We carried out an integrated transcriptome and proteome analysis of bladder samples from male patients with BOO before and 3 months after de-obstruction surgery (transurethral resection of the prostate, TURP). mRNA and protein profiles were correlated with urodynamic findings, specifically voiding detrusor pressure (PdetQmax) before TURP. Patients with high PdetQmax showed less advanced remodeling and inflammatory changes than those with lower values. We oberved significant dysregulation of gene expression, which was reversed by de-obstruction in both patients’ groups. We propose a series of biomarker genes, indicative of BOO, and possibly contributing to the bladder changes. Our data sheds light on the stages of progressive obstruction-induced bladder decompensation, and might add selecting the operation point to avoid the loss of contractility. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-21 |
AnnouncementXML | Submission_2024-05-21_07:16:39.153.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Manfred Heller |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-23 01:50:51 | ID requested | |
⏵ 1 | 2024-05-21 07:16:39 | announced | |
Publication List
10.1186/s12894-024-01417-8; |
Akshay A, Gheinani AH, Besic M, Braga S, Uldry AC, Heller M, Rehrauer H, Fournier CA, Burkhard FC, Monastyrskaya K, De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors. BMC Urol, 24(1):33(2024) [pubmed] |
Keyword List
submitter keyword: remodelling,bladder, fibrosis, outlet obstruction |
Contact List
Katia Monastyrskaya |
contact affiliation | Functional Urology Research Lab, DBMR, University of Bern, 3008 Bern, Switzerland |
contact email | katia.monastyrskaia@unibe.ch |
lab head | |
Manfred Heller |
contact affiliation | Proteomics and Mass Spectrometry Core Facility, Departement for Biomedical Research, University of Berne |
contact email | pmscf.dbmr@unibe.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044777
- Label: PRIDE project
- Name: De-obstruction of bladder outlet in humans reverses organ remodeling