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PXD044703-1

PXD044703 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIn-depth proteome profiling of ovarian cancer FFPE tissues associated with therapeutic response to PARP inhibitor
DescriptionThe recent introduction of poly ADP-ribose polymerase (PARP) inhibitors has significantly improved the survival outcomes of ovarian cancer. This study aimed to identify protein biomarkers and signatures predicting therapeutic responses to PARP inhibitors in high-grade serous ovarian cancer (HGSOC). To identify prognostic biomarkers, we conducted an in-depth proteomic analysis on formalin-fixed paraffin-embedded (FFPE) cancer tissues obtained from 24 HGSOC patients who received PARP inhibitor maintenance therapy for platinum-sensitive recurrence. In total, 7825 proteins were quantified with the tandem mass tag (TMT) labelling method. There were 56 and 131 proteins significantly upregulated in the good and poor response groups, respectively.
HostingRepositoryPRIDE
AnnounceDate2024-05-21
AnnouncementXMLSubmission_2024-05-21_15:22:13.679.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDohyun Han
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-08-21 10:34:11ID requested
12024-05-21 15:22:14announced
22024-10-22 06:40:54announced2024-10-22: Updated project metadata.
Publication List
10.1002/ctm2.1693;
Kim SI, Kim H, Dan K, Park HB, Lee C, Kim HS, Chung HH, Kim JW, Park NH, Han D, Lee M, Proteomic landscaping of high-grade serous ovarian carcinoma identifies stearoyl-CoA desaturase 5 as a potential predictive biomarker for poly(ADP-ribose) polymerase inhibitor response. Clin Transl Med, 14(5):e1693(2024) [pubmed]
Keyword List
submitter keyword: Human, PARP inhibitor, Ovarian cancer, therapeutic response
Contact List
Dohyun Han
contact affiliationProteomics core facility, Biomedical Research Institute, Seoul National University Hospital
contact emailhdh03@snu.ac.kr
lab head
Dohyun Han
contact affiliationProteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital
contact emailhdh03@snu.ac.kr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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