PXD044680 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeting cancer-derived extracellular vesicles by combining CD147 inhibition and tissue factor pathway inhibitor for the management of urothelial cancer cells |
Description | Cancer cells release small particles or vesicles, which have the potency to induce cancer cells to spread and grow. In this study, we focused on two molecules presented by cell-derived vesicles that might promote cancer cells spread: a clotting protein and a cell surface protein. We found that vesicles from bladder cancer cells that could spread had higher levels of these proteins than vesicles from cancer cells that could not spread. We also found that these vesicles could make cancer cells move about more, produce more of a substance that helps cancer cells spread, and invade other tissues. To counteract the cancer-promoting actions of vesicles, we examined the impact of combining a naturally occurring anti-clotting protein that can be released by medications derived from heparin. We found that the combination could stop the vesicles from making cancer cells move about more, produce more of the spreading substance, and invade other tissues. These findings suggest that combining the inhibitor with medications derived from heparin to induce the release of the anti-clotting protein might be a new way to treat bladder cancer. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-21 |
AnnouncementXML | Submission_2024-05-21_11:37:09.248.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Thorben Sauer |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF fleX |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-08-21 01:13:26 | ID requested | |
⏵ 1 | 2024-05-21 11:37:10 | announced | |
Publication List
10.1186/s12964-024-01508-x; |
Boddu VK, Zamzow P, Kramer MW, Merseburger AS, Gorantla SP, Klinger M, Cramer L, Sauer T, Gemoll T, von Bubnoff N, Gieseler F, Darabi M, Targeting cancer-derived extracellular vesicles by combining CD147 inhibition with tissue factor pathway inhibitor for the management of urothelial cancer cells. Cell Commun Signal, 22(1):129(2024) [pubmed] |
Keyword List
submitter keyword: cancer-derived extracellular vesicles, urthelial cancer cells, CD147, tissue factor, signaling |
Contact List
Prof. Dr. Timo Gemoll |
contact affiliation | Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University of Lübeck and University Hospital Schleswig-Holstein, Campus Lübeck, Germany |
contact email | timo.gemoll@uni-luebeck.de |
lab head | |
Thorben Sauer |
contact affiliation | Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University of Lübeck and University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck Germany |
contact email | thorben.sauer@student.uni-luebeck.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD044680
- Label: PRIDE project
- Name: Targeting cancer-derived extracellular vesicles by combining CD147 inhibition and tissue factor pathway inhibitor for the management of urothelial cancer cells